Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825032..825692 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag M3N94_RS03960 Protein ID WP_000244756.1
Coordinates 825279..825692 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag M3N94_RS03955 Protein ID WP_000351186.1
Coordinates 825032..825298 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS03935 (820961) 820961..822394 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
M3N94_RS03940 (822552) 822552..822863 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
M3N94_RS03945 (823027) 823027..823686 + 660 WP_000250289.1 hemolysin III family protein -
M3N94_RS03950 (823802) 823802..824782 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
M3N94_RS03955 (825032) 825032..825298 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
M3N94_RS03960 (825279) 825279..825692 + 414 WP_000244756.1 protein YgfX Toxin
M3N94_RS03965 (825745) 825745..826266 - 522 WP_001055885.1 flavodoxin FldB -
M3N94_RS03970 (826379) 826379..827275 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
M3N94_RS03975 (827299) 827299..828012 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3N94_RS03980 (828018) 828018..829751 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T245074 WP_000244756.1 NZ_CP097262:825279-825692 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT245074 WP_000351186.1 NZ_CP097262:825032-825298 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References