Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200177..200937 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag M3N94_RS00925 Protein ID WP_000533912.1
Coordinates 200452..200937 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag M3N94_RS00920 Protein ID WP_000965886.1
Coordinates 200177..200464 (+) Length 96 a.a.

Genomic Context

M3N94_RS00900M3N94_RS00905M3N94_RS00910M3N94_RS00915M3N94_RS00920M3N94_RS00925M3N94_RS00945M3N94_RS00930M3N94_RS00935M3N94_RS00940M3N94_RS00950M3N94_RS00955
Location: 195582..196493 (912 bp)
Type: Others
Protein ID: WP_001168551.1
Location: 196503..198572 (2070 bp)
Type: Others
Protein ID: WP_001291741.1
Location: 198962..199360 (399 bp)
Type: Others
Protein ID: Protein_181
Location: 199532..199999 (468 bp)
Type: Others
Protein ID: WP_000702452.1
Location: 200177..200464 (288 bp)
Type: Antitoxin
Protein ID: WP_000965886.1
Location: 200452..200937 (486 bp)
Type: Toxin
Protein ID: WP_000533912.1
Location: 203250..203960 (711 bp)
Type: Others
Protein ID: WP_000190524.1
Location: 201308..201847 (540 bp)
Type: Others
Protein ID: WP_000047147.1
Location: 202021..202233 (213 bp)
Type: Others
Protein ID: WP_000014594.1
Location: 202521..202811 (291 bp)
Type: Others
Protein ID: WP_000455790.1
Location: 204010..204984 (975 bp)
Type: Others
Protein ID: WP_000804678.1
Location: 205203..205865 (663 bp)
Type: Others
Protein ID: WP_000747548.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M3N94_RS00900 (195582)195582..196493+912WP_001168551.1glycine--tRNA ligase subunit alpha-
M3N94_RS00905 (196503)196503..198572+2070WP_001291741.1glycine--tRNA ligase subunit beta-
M3N94_RS00910 (198962)198962..199360+399Protein_181IS3 family transposase-
M3N94_RS00915 (199532)199532..199999+468WP_000702452.1GNAT family N-acetyltransferase-
M3N94_RS00920 (200177)200177..200464+288WP_000965886.1DUF1778 domain-containing proteinAntitoxin
M3N94_RS00925 (200452)200452..200937+486WP_000533912.1GNAT family N-acetyltransferaseToxin
M3N94_RS00930 (201308)201308..201847-540WP_000047147.1copper-binding periplasmic metallochaperone CueP-
M3N94_RS00935 (202021)202021..202233-213WP_000014594.1RNA chaperone/antiterminator CspA-
M3N94_RS00940 (202521)202521..202811-291WP_000455790.1HTH-type transcriptional regulator-
M3N94_RS00945 (203250)203250..203960+711WP_000190524.1DUF3053 domain-containing protein-
M3N94_RS00950 (204010)204010..204984-975WP_000804678.1glyoxylate/hydroxypyruvate reductase GhrB-
M3N94_RS00955 (205203)205203..205865-663WP_000747548.1OmpA family lipoprotein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T245071 WP_000533912.1 NZ_CP097262:200452-200937 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT245071 WP_000965886.1 NZ_CP097262:200177-200464 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1R2W0C7

Antitoxin

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Source
ID
Structure
PDB7AK8
AlphaFold DBA0A3V2JDX2

References