Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2731047..2731660 Replicon chromosome
Accession NC_013716
Organism Citrobacter rodentium ICC168

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag ROD_RS12740 Protein ID WP_012906750.1
Coordinates 2731047..2731226 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D2TUQ0
Locus tag ROD_RS12745 Protein ID WP_012906751.1
Coordinates 2731250..2731660 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ROD_RS12725 2727056..2728822 + 1767 WP_012906747.1 ATP-binding cassette domain-containing protein -
ROD_RS12730 2728830..2729993 + 1164 WP_012906748.1 HlyD family efflux transporter periplasmic adaptor subunit -
ROD_RS12735 2730699..2730944 + 246 WP_012906749.1 DinI family protein -
ROD_RS12740 2731047..2731226 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
ROD_RS12745 2731250..2731660 + 411 WP_012906751.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ROD_RS12750 2731688..2732239 + 552 WP_148222088.1 serine acetyltransferase -
ROD_RS12755 2732255..2732833 - 579 WP_012906753.1 tail fiber assembly protein -
ROD_RS12760 2732833..2733681 - 849 WP_012906754.1 phage tail protein -
ROD_RS12765 2733735..2734340 - 606 WP_012906755.1 DUF2313 domain-containing protein -
ROD_RS12770 2734337..2735494 - 1158 WP_012906756.1 baseplate J/gp47 family protein -
ROD_RS12775 2735484..2735936 - 453 WP_012906757.1 phage GP46 family protein -
ROD_RS12780 2735933..2736517 - 585 WP_012906758.1 phage baseplate assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2727056..2778099 51043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T24507 WP_012906750.1 NC_013716:2731047-2731226 [Citrobacter rodentium ICC168]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T24507 NC_013716:2731047-2731226 [Citrobacter rodentium ICC168]
ATGGATAGCAGGAATGCGATAGCAATGATTGAAGCTGACGGGTGGTATCTGGTGAGAGTAAAAGGTAGTCATCACCAGTT
TAAGCACCCAACCAAGAAAGGGCTGGTAACGGTGAAACATCCACAGAAAGATATACCGCTACCAACACTCAAAAGCATCA
AGAAACAGGCGGGGCTCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14859.78 Da        Isoelectric Point: 4.3623

>AT24507 WP_012906751.1 NC_013716:2731250-2731660 [Citrobacter rodentium ICC168]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEAVPEATSVENWLADPDYTGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT24507 NC_013716:2731250-2731660 [Citrobacter rodentium ICC168]
ATGTTATATCCCGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCAGGCTGCTTCTCTGG
CGGCGACAACTATCAGGATGCGATAGAGAGCGTGCGTGAGGCTATCGACGCACATATCGAATTACTGGTGGAAGATGGTG
AAGCGGTGCCGGAAGCTACCAGCGTGGAAAACTGGCTCGCAGATCCCGATTATACAGGCGTAGTATGGGCACTGGTGGAT
GTAGACGTTACCCGGTTAATGGGGAAAGCAGAAAAAATCAACGTAACGCTTCCCTCTTTGCTGATCCGTCGTATCGATCA
ATTTGTTGCCGCTCATCCCGAATATGGTAGCCGCTCAGGCTTCCTGTCACGTGTGGCTGCTGATAAAGTGATCGGACGGG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB D2TUQ0

References