245062

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4408510..4409768 Replicon chromosome
Accession NZ_CP097256
Organism Pseudomonas aeruginosa strain D5

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M4954_RS20340 Protein ID WP_003163133.1
Coordinates 4408510..4409265 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M4954_RS20345 Protein ID WP_003086329.1
Coordinates 4409400..4409768 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4954_RS20330 (M4954_20330) 4403681..4406224 + 2544 WP_003120631.1 acyl-homoserine-lactone acylase QuiP -
M4954_RS20335 (M4954_20335) 4406380..4407741 - 1362 WP_003120632.1 DNA recombination protein RmuC -
M4954_RS20340 (M4954_20340) 4408510..4409265 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
M4954_RS20345 (M4954_20345) 4409400..4409768 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M4954_RS20350 (M4954_20350) 4409841..4411127 - 1287 WP_023096923.1 FAD-binding oxidoreductase -
M4954_RS20355 (M4954_20355) 4411183..4412676 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M4954_RS20360 (M4954_20360) 4412851..4413327 + 477 WP_003112531.1 hypothetical protein -
M4954_RS20365 (M4954_20365) 4413330..4413605 - 276 WP_201268585.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T245062 WP_003163133.1 NZ_CP097256:c4409265-4408510 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245062 WP_003086329.1 NZ_CP097256:c4409768-4409400 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References