245061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3472319..3473540 Replicon chromosome
Accession NZ_CP097256
Organism Pseudomonas aeruginosa strain D5

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M4954_RS15945 Protein ID WP_003102740.1
Coordinates 3472962..3473540 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M4954_RS15940 Protein ID WP_003088112.1
Coordinates 3472319..3472873 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4954_RS15915 (M4954_15915) 3467887..3468438 + 552 WP_003102727.1 XRE family transcriptional regulator -
M4954_RS15920 (M4954_15920) 3468435..3468833 - 399 WP_003102731.1 NADH-quinone oxidoreductase subunit A -
M4954_RS15925 (M4954_15925) 3468846..3469169 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M4954_RS15930 (M4954_15930) 3469500..3469961 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M4954_RS15935 (M4954_15935) 3469966..3472161 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M4954_RS15940 (M4954_15940) 3472319..3472873 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M4954_RS15945 (M4954_15945) 3472962..3473540 + 579 WP_003102740.1 HD domain-containing protein Toxin
M4954_RS15950 (M4954_15950) 3473649..3474836 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M4954_RS15955 (M4954_15955) 3474826..3476997 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
M4954_RS15960 (M4954_15960) 3476987..3478264 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T245061 WP_003102740.1 NZ_CP097256:3472962-3473540 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT245061 WP_003088112.1 NZ_CP097256:3472319-3472873 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References