245059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 140858..141363 Replicon chromosome
Accession NZ_CP097256
Organism Pseudomonas aeruginosa strain D5

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M4954_RS00645 Protein ID WP_003083773.1
Coordinates 140858..141139 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M4954_RS00650 Protein ID WP_003083775.1
Coordinates 141136..141363 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4954_RS00620 (M4954_00620) 136109..137458 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M4954_RS00625 (M4954_00625) 137507..138193 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M4954_RS00630 (M4954_00630) 138294..139028 + 735 WP_004346926.1 GntR family transcriptional regulator -
M4954_RS00635 (M4954_00635) 139208..139618 + 411 WP_003101225.1 aegerolysin family protein -
M4954_RS00640 (M4954_00640) 139650..140558 - 909 WP_003083769.1 LysR family transcriptional regulator -
M4954_RS00645 (M4954_00645) 140858..141139 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M4954_RS00650 (M4954_00650) 141136..141363 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M4954_RS00655 (M4954_00655) 141539..142159 - 621 WP_003101226.1 hypothetical protein -
M4954_RS00660 (M4954_00660) 142260..142760 + 501 WP_003101228.1 LEA type 2 family protein -
M4954_RS00665 (M4954_00665) 142833..143174 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M4954_RS00670 (M4954_00670) 143256..144683 - 1428 WP_003083784.1 GABA permease -
M4954_RS00675 (M4954_00675) 144852..146345 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245059 WP_003083773.1 NZ_CP097256:c141139-140858 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245059 WP_003083775.1 NZ_CP097256:c141363-141136 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References