Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3780849..3781506 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag M1V99_RS18390 Protein ID WP_028014322.1
Coordinates 3780849..3781259 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag M1V99_RS18395 Protein ID WP_010435322.1
Coordinates 3781240..3781506 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS18370 (M1V99_18370) 3776842..3778575 - 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -
M1V99_RS18375 (M1V99_18375) 3778581..3779294 - 714 WP_028014319.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M1V99_RS18380 (M1V99_18380) 3779323..3780219 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
M1V99_RS18385 (M1V99_18385) 3780321..3780842 + 522 WP_182034214.1 flavodoxin FldB -
M1V99_RS18390 (M1V99_18390) 3780849..3781259 - 411 WP_028014322.1 protein YgfX Toxin
M1V99_RS18395 (M1V99_18395) 3781240..3781506 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
M1V99_RS18400 (M1V99_18400) 3781801..3782781 + 981 WP_028014323.1 tRNA-modifying protein YgfZ -
M1V99_RS18405 (M1V99_18405) 3782869..3783528 - 660 WP_023331242.1 hemolysin III family protein -
M1V99_RS18410 (M1V99_18410) 3783794..3784525 + 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
M1V99_RS18415 (M1V99_18415) 3784642..3786075 + 1434 WP_028014326.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T245057 WP_028014322.1 NZ_CP097255:c3781259-3780849 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT245057 WP_010435322.1 NZ_CP097255:c3781506-3781240 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References