Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2954717..2955307 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag M1V99_RS14640 Protein ID WP_182035647.1
Coordinates 2954717..2955049 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8E1V487
Locus tag M1V99_RS14645 Protein ID WP_041909206.1
Coordinates 2955050..2955307 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS14625 (M1V99_14625) 2950382..2951725 + 1344 WP_047062999.1 enolase C-terminal domain-like protein -
M1V99_RS22505 2951735..2951866 + 132 WP_255467567.1 hypothetical protein -
M1V99_RS14630 (M1V99_14630) 2952028..2953079 + 1052 Protein_2764 IS3 family transposase -
M1V99_RS14635 (M1V99_14635) 2953200..2954314 - 1115 Protein_2765 IS30 family transposase -
M1V99_RS14640 (M1V99_14640) 2954717..2955049 - 333 WP_182035647.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M1V99_RS14645 (M1V99_14645) 2955050..2955307 - 258 WP_041909206.1 antitoxin Antitoxin
M1V99_RS14650 (M1V99_14650) 2955585..2956544 - 960 WP_182035648.1 zinc-binding alcohol dehydrogenase family protein -
M1V99_RS14655 (M1V99_14655) 2956593..2956982 - 390 WP_182035649.1 RidA family protein -
M1V99_RS14660 (M1V99_14660) 2957124..2958044 + 921 WP_182035650.1 LysR family transcriptional regulator -
M1V99_RS14665 (M1V99_14665) 2958205..2959491 - 1287 WP_249488108.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11841.76 Da        Isoelectric Point: 10.2965

>T245055 WP_182035647.1 NZ_CP097255:c2955049-2954717 [Enterobacter bugandensis]
MDRGEIWLVSLDPIAGHEQSGKRPVLVVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTMGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9449.95 Da        Isoelectric Point: 4.6234

>AT245055 WP_041909206.1 NZ_CP097255:c2955307-2955050 [Enterobacter bugandensis]
MYKTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References