Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1103408..1104028 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag M1V99_RS05790 Protein ID WP_008499287.1
Coordinates 1103408..1103626 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8E1RNX1
Locus tag M1V99_RS05795 Protein ID WP_028012188.1
Coordinates 1103654..1104028 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS05760 (M1V99_05760) 1099419..1099679 + 261 WP_194386085.1 type B 50S ribosomal protein L31 -
M1V99_RS05765 (M1V99_05765) 1099682..1099822 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M1V99_RS05770 (M1V99_05770) 1099819..1100529 - 711 WP_088205223.1 GNAT family protein -
M1V99_RS05775 (M1V99_05775) 1100631..1102091 + 1461 WP_194385901.1 PLP-dependent aminotransferase family protein -
M1V99_RS05780 (M1V99_05780) 1102063..1102530 - 468 WP_028012186.1 YlaC family protein -
M1V99_RS05785 (M1V99_05785) 1102647..1103198 - 552 WP_028012187.1 maltose O-acetyltransferase -
M1V99_RS05790 (M1V99_05790) 1103408..1103626 - 219 WP_008499287.1 HHA domain-containing protein Toxin
M1V99_RS05795 (M1V99_05795) 1103654..1104028 - 375 WP_028012188.1 Hha toxicity modulator TomB Antitoxin
M1V99_RS05800 (M1V99_05800) 1104538..1107684 - 3147 WP_047367620.1 multidrug efflux RND transporter permease subunit AcrB -
M1V99_RS05805 (M1V99_05805) 1107707..1108900 - 1194 WP_028012190.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T245050 WP_008499287.1 NZ_CP097255:c1103626-1103408 [Enterobacter bugandensis]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.30 Da        Isoelectric Point: 4.8886

>AT245050 WP_028012188.1 NZ_CP097255:c1104028-1103654 [Enterobacter bugandensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure

References