Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 152436..153043 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name hicA Uniprot ID A0A2T4Y605
Locus tag M1V99_RS01300 Protein ID WP_041911637.1
Coordinates 152436..152621 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M1V99_RS01305 Protein ID WP_249488262.1
Coordinates 152636..153043 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS01280 (M1V99_01280) 147818..148702 - 885 WP_249488259.1 ROK family protein -
M1V99_RS01285 (M1V99_01285) 148868..150406 + 1539 WP_249488260.1 aldehyde dehydrogenase AldB -
M1V99_RS01290 (M1V99_01290) 150403..151368 - 966 WP_249488261.1 LysR family transcriptional regulator -
M1V99_RS01295 (M1V99_01295) 151486..152226 + 741 WP_028015056.1 MipA/OmpV family protein -
M1V99_RS01300 (M1V99_01300) 152436..152621 + 186 WP_041911637.1 type II toxin-antitoxin system HicA family toxin Toxin
M1V99_RS01305 (M1V99_01305) 152636..153043 + 408 WP_249488262.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M1V99_RS01310 (M1V99_01310) 153047..154123 - 1077 WP_060572008.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
M1V99_RS01315 (M1V99_01315) 154330..156279 - 1950 WP_249488263.1 glycoside hydrolase family 127 protein -
M1V99_RS01320 (M1V99_01320) 156290..157690 - 1401 WP_249488264.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6852.04 Da        Isoelectric Point: 11.2341

>T245049 WP_041911637.1 NZ_CP097255:152436-152621 [Enterobacter bugandensis]
VKSADVITVLIGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15061.82 Da        Isoelectric Point: 4.3191

>AT245049 WP_249488262.1 NZ_CP097255:152636-153043 [Enterobacter bugandensis]
MFYPAYIHSDTDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGNVEVHLENHPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4Y605

Antitoxin

Source ID Structure

References