245045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5100334..5100869 Replicon chromosome
Accession NZ_CP097252
Organism Mesorhizobium opportunistum strain WSM1558

Toxin (Protein)


Gene name relE Uniprot ID F7Y055
Locus tag M5D98_RS24910 Protein ID WP_013895991.1
Coordinates 5100334..5100609 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F7Y056
Locus tag M5D98_RS24915 Protein ID WP_013895992.1
Coordinates 5100609..5100869 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D98_RS24885 (M5D98_24885) 5096354..5097265 - 912 WP_224689827.1 ABC transporter substrate-binding protein -
M5D98_RS24890 (M5D98_24890) 5097472..5098044 + 573 WP_013895987.1 NADPH-dependent FMN reductase -
M5D98_RS24895 (M5D98_24895) 5098053..5099264 - 1212 WP_224689826.1 MFS transporter -
M5D98_RS24900 (M5D98_24900) 5099261..5099761 - 501 WP_013895989.1 transcription antitermination factor NusB -
M5D98_RS24905 (M5D98_24905) 5099758..5100252 - 495 WP_224689825.1 6,7-dimethyl-8-ribityllumazine synthase -
M5D98_RS24910 (M5D98_24910) 5100334..5100609 - 276 WP_013895991.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5D98_RS24915 (M5D98_24915) 5100609..5100869 - 261 WP_013895992.1 ribbon-helix-helix domain-containing protein Antitoxin
M5D98_RS24920 (M5D98_24920) 5100939..5101556 - 618 WP_224689824.1 riboflavin synthase -
M5D98_RS24925 (M5D98_24925) 5101683..5102813 - 1131 WP_224689823.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
M5D98_RS24930 (M5D98_24930) 5102816..5103295 - 480 WP_013895995.1 transcriptional regulator NrdR -
M5D98_RS24935 (M5D98_24935) 5103453..5104031 - 579 WP_023780329.1 hypothetical protein -
M5D98_RS24940 (M5D98_24940) 5104215..5105528 - 1314 WP_224689822.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10496.05 Da        Isoelectric Point: 8.5620

>T245045 WP_013895991.1 NZ_CP097252:c5100609-5100334 [Mesorhizobium opportunistum]
MELKWTNKALSDLVRLHDFLAPANGPAAARAVQALAAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNATIS
VLRLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9614.05 Da        Isoelectric Point: 5.6921

>AT245045 WP_013895992.1 NZ_CP097252:c5100869-5100609 [Mesorhizobium opportunistum]
MDTKVITAHVPLPLAEKVDQLAARLDRPRGWIVKQALSAWVDLEEERRRLTLEALADVDAGRVIDHQAVQAWAESLGTDK
PLPVPR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F7Y055

Antitoxin

Source ID Structure
AlphaFold DB F7Y056

References