Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3159901..3160496 Replicon chromosome
Accession NZ_CP097252
Organism Mesorhizobium opportunistum strain WSM1558

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M5D98_RS15325 Protein ID WP_224690350.1
Coordinates 3160308..3160496 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5D98_RS15320 Protein ID WP_224690351.1
Coordinates 3159901..3160302 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D98_RS15295 (M5D98_15295) 3155013..3155189 + 177 WP_224690357.1 hypothetical protein -
M5D98_RS15300 (M5D98_15300) 3155340..3157256 + 1917 WP_224690356.1 diguanylate cyclase -
M5D98_RS15305 (M5D98_15305) 3157270..3158124 - 855 WP_224690354.1 helix-turn-helix transcriptional regulator -
M5D98_RS15310 (M5D98_15310) 3158222..3159106 + 885 WP_224690353.1 SDR family oxidoreductase -
M5D98_RS15315 (M5D98_15315) 3159117..3159815 - 699 WP_224690352.1 RibD family protein -
M5D98_RS15320 (M5D98_15320) 3159901..3160302 - 402 WP_224690351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5D98_RS15325 (M5D98_15325) 3160308..3160496 - 189 WP_224690350.1 type II toxin-antitoxin system HicA family toxin Toxin
M5D98_RS15330 (M5D98_15330) 3160846..3161793 + 948 WP_023767148.1 substrate-binding domain-containing protein -
M5D98_RS15335 (M5D98_15335) 3162032..3163627 + 1596 WP_224690552.1 sugar ABC transporter ATP-binding protein -
M5D98_RS15340 (M5D98_15340) 3163624..3164637 + 1014 WP_224690551.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7045.15 Da        Isoelectric Point: 11.8350

>T245041 WP_224690350.1 NZ_CP097252:c3160496-3160308 [Mesorhizobium opportunistum]
MNSADIIRLLEADGWFEVSRKGSHAQFKHRGKPGRVTVPHPRRDIPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14274.15 Da        Isoelectric Point: 4.2535

>AT245041 WP_224690351.1 NZ_CP097252:c3160302-3159901 [Mesorhizobium opportunistum]
MKQYIGLIHKDAGSDFGVSFPDFPGVITAGKDLDDARSMAEEALTLHIEGLVEDGDAIPEPSSLEAVMADADNRDGVAIL
VAVKTEARKTVRINVTLPDDVLQRIDAFAEAHGYTRSGFLAKAAEKVMELEMA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References