245034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1678445..1679057 Replicon chromosome
Accession NZ_CP097251
Organism Streptococcus pyogenes strain 21SPY7071 isolate cerebral abscess

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag M3N36_RS08540 Protein ID WP_002988077.1
Coordinates 1678722..1679057 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag M3N36_RS08535 Protein ID WP_002988079.1
Coordinates 1678445..1678732 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N36_RS08510 (M3N36_08510) 1673637..1674620 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
M3N36_RS08515 (M3N36_08515) 1674624..1675553 - 930 WP_030127320.1 tagatose-6-phosphate kinase -
M3N36_RS08520 (M3N36_08520) 1675599..1676114 - 516 WP_030127321.1 galactose-6-phosphate isomerase subunit LacB -
M3N36_RS08525 (M3N36_08525) 1676149..1676577 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
M3N36_RS08530 (M3N36_08530) 1677022..1677795 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
M3N36_RS08535 (M3N36_08535) 1678445..1678732 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
M3N36_RS08540 (M3N36_08540) 1678722..1679057 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3N36_RS08545 (M3N36_08545) 1679155..1680190 + 1036 Protein_1644 site-specific integrase -
M3N36_RS08550 (M3N36_08550) 1680322..1680714 - 393 WP_002982716.1 30S ribosomal protein S9 -
M3N36_RS08555 (M3N36_08555) 1680735..1681181 - 447 WP_011018228.1 50S ribosomal protein L13 -
M3N36_RS08560 (M3N36_08560) 1681399..1681605 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
M3N36_RS08565 (M3N36_08565) 1681602..1682300 - 699 WP_030127323.1 hypothetical protein -
M3N36_RS08570 (M3N36_08570) 1682436..1683296 - 861 WP_030127324.1 DegV family protein -
M3N36_RS08575 (M3N36_08575) 1683393..1683911 - 519 WP_011889154.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T245034 WP_002988077.1 NZ_CP097251:1678722-1679057 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT245034 WP_002988079.1 NZ_CP097251:1678445-1678732 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References