Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4680299..4681887 Replicon chromosome
Accession NZ_CP097248
Organism Klebsiella pneumoniae strain NTU107224

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag M5D84_RS22950 Protein ID WP_004176197.1
Coordinates 4680565..4681887 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M5D84_RS22945 Protein ID WP_002904790.1
Coordinates 4680299..4680565 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D84_RS22920 (4675449) 4675449..4676372 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
M5D84_RS22925 (4676353) 4676353..4677507 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5D84_RS22930 (4677853) 4677853..4679232 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M5D84_RS22935 (4679210) 4679210..4679710 + 501 WP_032434523.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5D84_RS22940 (4679707) 4679707..4680033 + 327 WP_002904788.1 hydroxyisourate hydrolase -
M5D84_RS22945 (4680299) 4680299..4680565 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5D84_RS22950 (4680565) 4680565..4681887 + 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
M5D84_RS22955 (4681904) 4681904..4683196 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5D84_RS22960 (4683338) 4683338..4684342 - 1005 WP_032434525.1 fimbrial protein -
M5D84_RS22965 (4684330) 4684330..4686831 - 2502 WP_087842418.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T245033 WP_004176197.1 NZ_CP097248:4680565-4681887 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT245033 WP_002904790.1 NZ_CP097248:4680299-4680565 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References