Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2947829..2948486 Replicon chromosome
Accession NZ_CP097248
Organism Klebsiella pneumoniae strain NTU107224

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5D84_RS14355 Protein ID WP_002916310.1
Coordinates 2948076..2948486 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5D84_RS14350 Protein ID WP_002916312.1
Coordinates 2947829..2948095 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D84_RS14325 (2942985) 2942985..2944418 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5D84_RS14330 (2944537) 2944537..2945265 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5D84_RS14335 (2945315) 2945315..2945626 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5D84_RS14340 (2945790) 2945790..2946449 + 660 WP_002916317.1 hemolysin III family protein -
M5D84_RS14345 (2946600) 2946600..2947583 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M5D84_RS14350 (2947829) 2947829..2948095 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5D84_RS14355 (2948076) 2948076..2948486 + 411 WP_002916310.1 protein YgfX Toxin
M5D84_RS14360 (2948493) 2948493..2949014 - 522 WP_004144730.1 flavodoxin FldB -
M5D84_RS14365 (2949115) 2949115..2950011 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5D84_RS14370 (2950034) 2950034..2950747 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5D84_RS14375 (2950753) 2950753..2952486 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T245028 WP_002916310.1 NZ_CP097248:2948076-2948486 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245028 WP_002916312.1 NZ_CP097248:2947829-2948095 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References