Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1561049..1561565 Replicon chromosome
Accession NZ_CP097248
Organism Klebsiella pneumoniae strain NTU107224

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag M5D84_RS07565 Protein ID WP_009309309.1
Coordinates 1561049..1561333 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5D84_RS07570 Protein ID WP_002886901.1
Coordinates 1561323..1561565 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D84_RS07540 (1556533) 1556533..1556841 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
M5D84_RS07545 (1556926) 1556926..1557099 + 174 Protein_1474 hypothetical protein -
M5D84_RS07550 (1557102) 1557102..1557845 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5D84_RS07555 (1558202) 1558202..1560340 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5D84_RS07560 (1560581) 1560581..1561045 + 465 WP_032418146.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5D84_RS07565 (1561049) 1561049..1561333 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5D84_RS07570 (1561323) 1561323..1561565 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5D84_RS07575 (1561643) 1561643..1563553 - 1911 WP_004152270.1 PRD domain-containing protein -
M5D84_RS07580 (1563576) 1563576..1564730 - 1155 WP_002886900.1 lactonase family protein -
M5D84_RS07585 (1564797) 1564797..1565537 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T245023 WP_009309309.1 NZ_CP097248:c1561333-1561049 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245023 WP_002886901.1 NZ_CP097248:c1561565-1561323 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References