Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1974274..1974872 Replicon chromosome
Accession NZ_CP097247
Organism Trueperella pyogenes strain 22/KM0800

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M5C92_RS08965 Protein ID WP_240628678.1
Coordinates 1974274..1974432 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5C92_RS08970 Protein ID WP_024963631.1
Coordinates 1974579..1974872 (+) Length 98 a.a.

Genomic Context

M5C92_RS08940M5C92_RS08945M5C92_RS08950M5C92_RS08965M5C92_RS08970M5C92_RS08975M5C92_RS09000M5C92_RS08935M5C92_RS08955M5C92_RS08960M5C92_RS08985M5C92_RS08990M5C92_RS08995
Location: 1970332..1970574 (243 bp)
Type: Others
Protein ID: WP_024963636.1
Location: 1970571..1971524 (954 bp)
Type: Others
Protein ID: WP_025296459.1
Location: 1971656..1972279 (624 bp)
Type: Others
Protein ID: WP_258486271.1
Location: 1974274..1974432 (159 bp)
Type: Toxin
Protein ID: WP_240628678.1
Location: 1974579..1974872 (294 bp)
Type: Antitoxin
Protein ID: WP_024963631.1
Location: 1974979..1975395 (417 bp)
Type: Others
Protein ID: WP_164716404.1
Location: 1978795..1979442 (648 bp)
Type: Others
Protein ID: WP_258486279.1
Location: 1969305..1970207 (903 bp)
Type: Others
Protein ID: WP_258486269.1
Location: 1972411..1972767 (357 bp)
Type: Others
Protein ID: WP_024963633.1
Location: 1973095..1973943 (849 bp)
Type: Others
Protein ID: WP_159074054.1
Location: 1975795..1976421 (627 bp)
Type: Others
Protein ID: WP_258486276.1
Location: 1976418..1977437 (1020 bp)
Type: Others
Protein ID: WP_258486277.1
Location: 1977497..1978711 (1215 bp)
Type: Others
Protein ID: WP_258486278.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M5C92_RS08935 (M5C92_08910)1969305..1970207-903WP_258486269.1ABC transporter substrate-binding protein-
M5C92_RS08940 (M5C92_08915)1970332..1970574+243WP_024963636.1hypothetical protein-
M5C92_RS08945 (M5C92_08920)1970571..1971524+954WP_025296459.1SRPBCC family protein-
M5C92_RS08950 (M5C92_08925)1971656..1972279+624WP_258486271.1alpha/beta hydrolase-
M5C92_RS08955 (M5C92_08930)1972411..1972767-357WP_024963633.1hypothetical protein-
M5C92_RS08960 (M5C92_08935)1973095..1973943-849WP_159074054.1siderophore-interacting protein-
M5C92_RS08965 (M5C92_08940)1974274..1974432+159WP_240628678.1hypothetical proteinToxin
M5C92_RS08970 (M5C92_08945)1974579..1974872+294WP_024963631.1putative addiction module antidote proteinAntitoxin
M5C92_RS08975 (M5C92_08950)1974979..1975395+417WP_164716404.1SRPBCC family protein-
M5C92_RS08985 (M5C92_08960)1975795..1976421-627WP_258486276.1alpha/beta hydrolase-
M5C92_RS08990 (M5C92_08965)1976418..1977437-1020WP_258486277.1hypothetical protein-
M5C92_RS08995 (M5C92_08970)1977497..1978711-1215WP_258486278.1molybdopterin molybdotransferase MoeA-
M5C92_RS09000 (M5C92_08975)1978795..1979442+648WP_258486279.15-formyltetrahydrofolate cyclo-ligase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-52)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5902.97 Da        Isoelectric Point: 10.5648

>T245020 WP_240628678.1 NZ_CP097247:1974274-1974432 [Trueperella pyogenes]
VKIRQTDVYARWFRKLKDVQGKARINIALQRCKIAGEVVGDVKPVGDGVFEM

Download         Length: 159 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10245.72 Da        Isoelectric Point: 4.5843

>AT245020 WP_024963631.1 NZ_CP097247:1974579-1974872 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWQTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References