Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1974274..1974872 Replicon chromosome
Accession NZ_CP097247
Organism Trueperella pyogenes strain 22/KM0800

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M5C92_RS08965 Protein ID WP_240628678.1
Coordinates 1974274..1974432 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5C92_RS08970 Protein ID WP_024963631.1
Coordinates 1974579..1974872 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5C92_RS08935 (M5C92_08910) 1969305..1970207 - 903 WP_258486269.1 ABC transporter substrate-binding protein -
M5C92_RS08940 (M5C92_08915) 1970332..1970574 + 243 WP_024963636.1 hypothetical protein -
M5C92_RS08945 (M5C92_08920) 1970571..1971524 + 954 WP_025296459.1 SRPBCC family protein -
M5C92_RS08950 (M5C92_08925) 1971656..1972279 + 624 WP_258486271.1 alpha/beta hydrolase -
M5C92_RS08955 (M5C92_08930) 1972411..1972767 - 357 WP_024963633.1 hypothetical protein -
M5C92_RS08960 (M5C92_08935) 1973095..1973943 - 849 WP_159074054.1 siderophore-interacting protein -
M5C92_RS08965 (M5C92_08940) 1974274..1974432 + 159 WP_240628678.1 hypothetical protein Toxin
M5C92_RS08970 (M5C92_08945) 1974579..1974872 + 294 WP_024963631.1 putative addiction module antidote protein Antitoxin
M5C92_RS08975 (M5C92_08950) 1974979..1975395 + 417 WP_164716404.1 SRPBCC family protein -
M5C92_RS08985 (M5C92_08960) 1975795..1976421 - 627 WP_258486276.1 alpha/beta hydrolase -
M5C92_RS08990 (M5C92_08965) 1976418..1977437 - 1020 WP_258486277.1 hypothetical protein -
M5C92_RS08995 (M5C92_08970) 1977497..1978711 - 1215 WP_258486278.1 molybdopterin molybdotransferase MoeA -
M5C92_RS09000 (M5C92_08975) 1978795..1979442 + 648 WP_258486279.1 5-formyltetrahydrofolate cyclo-ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-52)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5902.97 Da        Isoelectric Point: 10.5648

>T245020 WP_240628678.1 NZ_CP097247:1974274-1974432 [Trueperella pyogenes]
VKIRQTDVYARWFRKLKDVQGKARINIALQRCKIAGEVVGDVKPVGDGVFEM

Download         Length: 159 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10245.72 Da        Isoelectric Point: 4.5843

>AT245020 WP_024963631.1 NZ_CP097247:1974579-1974872 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWQTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References