Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3545039..3545670 Replicon chromosome
Accession NZ_CP097245
Organism Leptospira santarosai strain DCP-017

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5D10_RS16025 Protein ID WP_269025760.1
Coordinates 3545269..3545670 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5D10_RS16020 Protein ID WP_075918871.1
Coordinates 3545039..3545272 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D10_RS15995 (M5D10_15965) 3541689..3542336 - 648 WP_004460452.1 biosynthetic peptidoglycan transglycosylase -
M5D10_RS16000 (M5D10_15970) 3542339..3543001 - 663 WP_032919653.1 RibD family protein -
M5D10_RS16005 (M5D10_15975) 3542998..3543225 - 228 WP_004476676.1 (2Fe-2S)-binding protein -
M5D10_RS16010 (M5D10_15980) 3543321..3544721 + 1401 WP_052754255.1 MFS transporter -
M5D10_RS16015 (M5D10_15985) 3544819..3545028 + 210 WP_002629717.1 hypothetical protein -
M5D10_RS16020 (M5D10_15990) 3545039..3545272 + 234 WP_075918871.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5D10_RS16025 (M5D10_15995) 3545269..3545670 + 402 WP_269025760.1 type II toxin-antitoxin system VapC family toxin Toxin
M5D10_RS16030 (M5D10_16000) 3545925..3546160 + 236 Protein_3165 IS5/IS1182 family transposase -
M5D10_RS16035 (M5D10_16005) 3546195..3546989 - 795 WP_269025761.1 hypothetical protein -
M5D10_RS16040 (M5D10_16010) 3547034..3548290 + 1257 WP_269025763.1 hypothetical protein -
M5D10_RS16045 (M5D10_16015) 3548384..3548968 + 585 WP_004460438.1 cytochrome C oxidase subunit IV family protein -
M5D10_RS16050 (M5D10_16020) 3549155..3549799 + 645 WP_004460436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(11-49)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15569.32 Da        Isoelectric Point: 9.5697

>T245019 WP_269025760.1 NZ_CP097245:3545269-3545670 [Leptospira santarosai]
MTHYLLDTNICIYIINQKPESVYKKFKKIKLENIFISSITEFELKYDVQKSLHFERNLKVLEEFLGYLNILQFVSKDASK
AAKIRVELERVGKPIGPFDLLIASQALANKLTLVTNNEKEFARIKEIKMESWL

Download         Length: 402 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9217.29 Da        Isoelectric Point: 7.2001

>AT245019 WP_075918871.1 NZ_CP097245:3545039-3545272 [Leptospira santarosai]
IPHYSKERLQGDSQAIRLPKNYRFKGREVYIRKDGDNVILTPIDDIVDRFWNTLHNFSDDLIIDRNQPNEYDKRNGI

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References