Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1098980..1099545 Replicon chromosome
Accession NZ_CP097245
Organism Leptospira santarosai strain DCP-017

Toxin (Protein)


Gene name mazE Uniprot ID K8YH10
Locus tag M5D10_RS04870 Protein ID WP_004458030.1
Coordinates 1098980..1099303 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M5D10_RS04875 Protein ID WP_026053376.1
Coordinates 1099303..1099545 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D10_RS04855 (M5D10_04845) 1094817..1095512 - 696 WP_004464119.1 ABC transporter ATP-binding protein -
M5D10_RS04860 (M5D10_04850) 1095925..1097049 - 1125 WP_004458035.1 SpoIID/LytB domain-containing protein -
M5D10_RS04865 (M5D10_04855) 1097221..1098576 - 1356 WP_269026144.1 DNA adenine methylase -
M5D10_RS04870 (M5D10_04860) 1098980..1099303 - 324 WP_004458030.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M5D10_RS04875 (M5D10_04865) 1099303..1099545 - 243 WP_026053376.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M5D10_RS04880 (M5D10_04870) 1099980..1101071 - 1092 WP_269026146.1 DUF1565 domain-containing protein -
M5D10_RS04885 (M5D10_04875) 1101683..1102663 - 981 WP_269026147.1 transporter -
M5D10_RS04890 (M5D10_04880) 1102663..1103541 - 879 WP_269026148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12250.67 Da        Isoelectric Point: 10.3519

>T245015 WP_004458030.1 NZ_CP097245:c1099303-1098980 [Leptospira santarosai]
MVIAQYEVYLINLDPTIGYEIKKSRPCVIISPNEMNKTIGTIIIAPMTTKSRTYPTRIELTFQGKKGWIVLDQIRTVDKV
RLIKKLGKIDSKISNQLKSIIKEMLVD

Download         Length: 324 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9202.70 Da        Isoelectric Point: 5.8481

>AT245015 WP_026053376.1 NZ_CP097245:c1099545-1099303 [Leptospira santarosai]
MKVSVVKIGNSKGIRIPKAVLEECHIEDEVDLLINNNKLIVVPLKSKPREGWEKQFKTMSSNKDDKLLIPDSIDLSDWEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4L4R9

Antitoxin

Source ID Structure

References