Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 440032..440437 Replicon chromosome
Accession NZ_CP097245
Organism Leptospira santarosai strain DCP-017

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M5D10_RS01970 Protein ID WP_016754698.1
Coordinates 440032..440217 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5D10_RS01975 Protein ID WP_232227005.1
Coordinates 440234..440437 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D10_RS01950 (M5D10_01950) 436100..437146 + 1047 WP_269025990.1 tyrosine-type recombinase/integrase -
M5D10_RS01955 (M5D10_01955) 437552..438316 + 765 WP_269025991.1 ParA family protein -
M5D10_RS01960 (M5D10_01960) 438313..439542 + 1230 WP_269025992.1 chromosome partitioning protein ParB -
M5D10_RS01965 (M5D10_01965) 439539..439832 + 294 WP_269025993.1 hypothetical protein -
M5D10_RS01970 (M5D10_01970) 440032..440217 + 186 WP_016754698.1 type II toxin-antitoxin system HicA family toxin Toxin
M5D10_RS01975 (M5D10_01975) 440234..440437 + 204 WP_232227005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5D10_RS01980 (M5D10_01980) 442592..444175 + 1584 WP_269026417.1 C39 family peptidase -
M5D10_RS01985 (M5D10_01985) 444191..444874 + 684 WP_269025994.1 hypothetical protein -
M5D10_RS01990 (M5D10_01990) 444995..445199 + 205 Protein_392 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-63)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6909.09 Da        Isoelectric Point: 10.4744

>T245014 WP_016754698.1 NZ_CP097245:440032-440217 [Leptospira santarosai]
MKVKEIIKILEDDGWYLVDQRGSHRQFKHSLKYGRVTVAGKPSMDIPPGTLNSILKQSGLK

Download         Length: 186 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7278.39 Da        Isoelectric Point: 4.3344

>AT245014 WP_232227005.1 NZ_CP097245:440234-440437 [Leptospira santarosai]
MEYPVMIEKSSTGYGAYVPDLPGCVAVGETEAEVTRLIKEAIEFHLEGMRKDGEPIPNPSKVTLIAV

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References