Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 163052..163803 Replicon 1 plasmid p283.4
Accession NZ_CP097238
Organism Klebsiella pneumoniae strain

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag M4268_RS26630 Protein ID WP_014386536.1
Coordinates 163321..163803 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M4268_RS26625 Protein ID WP_004902250.1
Coordinates 163052..163330 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4268_RS26590 (M4268_26600) 158695..159120 - 426 WP_000522996.1 organomercurial transporter MerC -
M4268_RS26595 (M4268_26605) 159148..159423 - 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
M4268_RS26600 (M4268_26610) 159439..159804 - 366 WP_004200999.1 mercuric ion transporter MerT -
M4268_RS26605 (M4268_26615) 159876..160331 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
M4268_RS26610 (M4268_26620) 160984..161442 + 459 WP_014386535.1 hypothetical protein -
M4268_RS26615 (M4268_26625) 162272..162613 + 342 WP_004902257.1 hypothetical protein -
M4268_RS26620 (M4268_26630) 162721..162933 + 213 WP_004902255.1 hypothetical protein -
M4268_RS26625 (M4268_26635) 163052..163330 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M4268_RS26630 (M4268_26640) 163321..163803 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
M4268_RS26635 (M4268_26645) 164838..165377 + 540 WP_004902239.1 hypothetical protein -
M4268_RS26640 (M4268_26650) 165482..165874 + 393 WP_032442757.1 hypothetical protein -
M4268_RS26645 (M4268_26655) 165975..166730 + 756 WP_004902235.1 DUF2971 domain-containing protein -
M4268_RS26650 (M4268_26660) 166757..167404 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / blaOXA-1 / aac(6')-Ib-cr / qnrB1 / blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..283371 283371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T245012 WP_014386536.1 NZ_CP097238:163321-163803 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT245012 WP_004902250.1 NZ_CP097238:163052-163330 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References