Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 128394..129304 | Replicon | 1 plasmid p283.4 |
| Accession | NZ_CP097238 | ||
| Organism | Klebsiella pneumoniae strain | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | M4268_RS26440 | Protein ID | WP_004181896.1 |
| Coordinates | 128834..129304 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | M4268_RS26435 | Protein ID | WP_004181895.1 |
| Coordinates | 128394..128837 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M4268_RS26420 (M4268_26430) | 125027..126514 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| M4268_RS26425 (M4268_26435) | 126600..127022 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| M4268_RS26430 (M4268_26440) | 127022..128293 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M4268_RS26435 (M4268_26445) | 128394..128837 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| M4268_RS26440 (M4268_26450) | 128834..129304 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| M4268_RS26445 (M4268_26455) | 129414..129674 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| M4268_RS26450 (M4268_26460) | 130397..130555 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| M4268_RS26455 (M4268_26465) | 131158..132132 | + | 975 | WP_043907013.1 | hypothetical protein | - |
| M4268_RS26460 (M4268_26470) | 132330..132707 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | dfrA14 / blaOXA-1 / aac(6')-Ib-cr / qnrB1 / blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | - | 1..283371 | 283371 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T245011 WP_004181896.1 NZ_CP097238:128834-129304 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT245011 WP_004181895.1 NZ_CP097238:128394-128837 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |