Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4632511..4634099 Replicon chromosome
Accession NZ_CP097237
Organism Klebsiella pneumoniae strain

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M4268_RS22260 Protein ID WP_004179815.1
Coordinates 4632511..4633833 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M4268_RS22265 Protein ID WP_004176198.1
Coordinates 4633833..4634099 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4268_RS22245 (4627567) 4627567..4630068 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
M4268_RS22250 (4630056) 4630056..4631060 + 1005 WP_004179822.1 fimbrial protein -
M4268_RS22255 (4631202) 4631202..4632494 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M4268_RS22260 (4632511) 4632511..4633833 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M4268_RS22265 (4633833) 4633833..4634099 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M4268_RS22270 (4634365) 4634365..4634691 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M4268_RS22275 (4634688) 4634688..4635188 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M4268_RS22280 (4635166) 4635166..4636545 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M4268_RS22285 (4636891) 4636891..4638045 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M4268_RS22290 (4638026) 4638026..4638949 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T245010 WP_004179815.1 NZ_CP097237:c4633833-4632511 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT245010 WP_004176198.1 NZ_CP097237:c4634099-4633833 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References