Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2429547..2430357 Replicon chromosome
Accession NZ_CP097237
Organism Klebsiella pneumoniae strain

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag M4268_RS11645 Protein ID WP_004178461.1
Coordinates 2429824..2430357 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M4268_RS11640 Protein ID WP_002887278.1
Coordinates 2429547..2429813 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4268_RS11620 (2425419) 2425419..2425763 - 345 WP_004197273.1 cation efflux system protein CusF -
M4268_RS11625 (2425781) 2425781..2427166 - 1386 WP_004178457.1 efflux transporter outer membrane subunit -
M4268_RS11630 (2427338) 2427338..2428021 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
M4268_RS11635 (2428011) 2428011..2429444 + 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
M4268_RS11640 (2429547) 2429547..2429813 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M4268_RS11645 (2429824) 2429824..2430357 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
M4268_RS11650 (2430405) 2430405..2431526 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T245003 WP_004178461.1 NZ_CP097237:2429824-2430357 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245003 WP_002887278.1 NZ_CP097237:2429547-2429813 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References