Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2319273..2319789 Replicon chromosome
Accession NZ_CP097237
Organism Klebsiella pneumoniae strain

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4268_RS11205 Protein ID WP_004178374.1
Coordinates 2319505..2319789 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4268_RS11200 Protein ID WP_002886901.1
Coordinates 2319273..2319515 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4268_RS11185 (2315301) 2315301..2316041 + 741 WP_002886899.1 KDGP aldolase family protein -
M4268_RS11190 (2316108) 2316108..2317262 + 1155 WP_004178372.1 lactonase family protein -
M4268_RS11195 (2317285) 2317285..2319195 + 1911 WP_004178373.1 PRD domain-containing protein -
M4268_RS11200 (2319273) 2319273..2319515 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4268_RS11205 (2319505) 2319505..2319789 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4268_RS11210 (2319793) 2319793..2320257 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4268_RS11215 (2320498) 2320498..2322636 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4268_RS11220 (2322993) 2322993..2323736 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4268_RS11225 (2323739) 2323739..2323912 - 174 WP_032408826.1 hypothetical protein -
M4268_RS11230 (2324042) 2324042..2324305 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T245002 WP_004178374.1 NZ_CP097237:2319505-2319789 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245002 WP_002886901.1 NZ_CP097237:2319273-2319515 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References