Detailed information of TA system TA245001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2162413..2164094
• Replicon: chromosome
• Accession: NZ_CP097237
• Organism: Klebsiella pneumoniae strain

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M4268_RS10410
• Protein ID: WP_004178299.1
• Coordinates: 2163177..2164094 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M4268_RS10405
• Protein ID: WP_004177809.1
• Coordinates: 2162413..2163171 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M4268_RS10390 (2158263)	2158263..2158949	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
M4268_RS10395 (2159179)	2159179..2161326	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M4268_RS10400 (2161599)	2161599..2162327	+	729	WP_004178298.1	response regulator transcription factor	-
M4268_RS10405 (2162413)	2162413..2163171	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M4268_RS10410 (2163177)	2163177..2164094	+	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M4268_RS10415 (2164219)	2164219..2165226	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
M4268_RS10420 (2165301)	2165301..2166242	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M4268_RS10425 (2166273)	2166273..2167271	-	999	WP_002885172.1	ribose ABC transporter permease	-
M4268_RS10430 (2167268)	2167268..2168788	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T245001 WP_004178299.1 NZ_CP097237:2163177-2164094 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT245001 WP_004177809.1 NZ_CP097237:2162413-2163171 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05