Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 944513..945170 Replicon chromosome
Accession NZ_CP097237
Organism Klebsiella pneumoniae strain

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M4268_RS04550 Protein ID WP_004181233.1
Coordinates 944513..944923 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M4268_RS04555 Protein ID WP_002916312.1
Coordinates 944904..945170 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4268_RS04530 (940513) 940513..942246 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
M4268_RS04535 (942252) 942252..942965 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4268_RS04540 (942988) 942988..943884 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M4268_RS04545 (943985) 943985..944506 + 522 WP_004144730.1 flavodoxin FldB -
M4268_RS04550 (944513) 944513..944923 - 411 WP_004181233.1 protein YgfX Toxin
M4268_RS04555 (944904) 944904..945170 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M4268_RS04560 (945416) 945416..946399 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M4268_RS04565 (946550) 946550..947209 - 660 WP_002916317.1 hemolysin III family protein -
M4268_RS04570 (947373) 947373..947684 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M4268_RS04575 (947734) 947734..948462 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M4268_RS04580 (948581) 948581..950014 + 1434 WP_004181234.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T244998 WP_004181233.1 NZ_CP097237:c944923-944513 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244998 WP_002916312.1 NZ_CP097237:c945170-944904 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References