Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3285599..3286224 Replicon chromosome
Accession NZ_CP097232
Organism Klebsiella pneumoniae strain 4

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M4269_RS15820 Protein ID WP_002882817.1
Coordinates 3285599..3285982 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M4269_RS15825 Protein ID WP_004150355.1
Coordinates 3285982..3286224 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4269_RS15805 (3282965) 3282965..3283867 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M4269_RS15810 (3283864) 3283864..3284499 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M4269_RS15815 (3284496) 3284496..3285425 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M4269_RS15820 (3285599) 3285599..3285982 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M4269_RS15825 (3285982) 3285982..3286224 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M4269_RS15830 (3286429) 3286429..3287346 + 918 WP_004181612.1 alpha/beta hydrolase -
M4269_RS15835 (3287360) 3287360..3288301 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M4269_RS15840 (3288346) 3288346..3288783 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M4269_RS15845 (3288780) 3288780..3289640 - 861 WP_004146232.1 virulence factor BrkB family protein -
M4269_RS15850 (3289634) 3289634..3290233 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T244992 WP_002882817.1 NZ_CP097232:c3285982-3285599 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT244992 WP_004150355.1 NZ_CP097232:c3286224-3285982 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References