Detailed information of TA system TA244991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2972840..2974521
• Replicon: chromosome
• Accession: NZ_CP097232
• Organism: Klebsiella pneumoniae strain 4

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M4269_RS14385
• Protein ID: WP_004178299.1
• Coordinates: 2972840..2973757 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M4269_RS14390
• Protein ID: WP_004177809.1
• Coordinates: 2973763..2974521 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M4269_RS14365 (2968146)	2968146..2969666	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M4269_RS14370 (2969663)	2969663..2970661	+	999	WP_002885172.1	ribose ABC transporter permease	-
M4269_RS14375 (2970692)	2970692..2971633	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M4269_RS14380 (2971708)	2971708..2972715	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M4269_RS14385 (2972840)	2972840..2973757	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M4269_RS14390 (2973763)	2973763..2974521	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M4269_RS14395 (2974607)	2974607..2975335	-	729	WP_004178298.1	response regulator transcription factor	-
M4269_RS14400 (2975608)	2975608..2977755	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M4269_RS14405 (2977985)	2977985..2978671	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T244991 WP_004178299.1 NZ_CP097232:c2973757-2972840 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT244991 WP_004177809.1 NZ_CP097232:c2974521-2973763 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05