Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2972840..2974521 Replicon chromosome
Accession NZ_CP097232
Organism Klebsiella pneumoniae strain 4

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag M4269_RS14385 Protein ID WP_004178299.1
Coordinates 2972840..2973757 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M4269_RS14390 Protein ID WP_004177809.1
Coordinates 2973763..2974521 (-) Length 253 a.a.

Genomic Context


M4269_RS14365M4269_RS14370M4269_RS14375M4269_RS14380M4269_RS14400M4269_RS14405M4269_RS14385M4269_RS14390M4269_RS14395
Location: 2968146..2969666 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
Location: 2969663..2970661 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Location: 2970692..2971633 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Location: 2971708..2972715 (1008 bp)
Type: Others
Protein ID: WP_004178300.1
Location: 2975608..2977755 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Location: 2977985..2978671 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Location: 2972840..2973757 (918 bp)
Type: Toxin
Protein ID: WP_004178299.1
Location: 2973763..2974521 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 2974607..2975335 (729 bp)
Type: Others
Protein ID: WP_004178298.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M4269_RS14365 (2968146)2968146..2969666+1521WP_002885173.1sugar ABC transporter ATP-binding protein-
M4269_RS14370 (2969663)2969663..2970661+999WP_002885172.1ribose ABC transporter permease-
M4269_RS14375 (2970692)2970692..2971633+942WP_002885156.1ABC transporter substrate-binding protein-
M4269_RS14380 (2971708)2971708..2972715+1008WP_004178300.1carbohydrate kinase family protein-
M4269_RS14385 (2972840)2972840..2973757-918WP_004178299.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
M4269_RS14390 (2973763)2973763..2974521-759WP_004177809.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
M4269_RS14395 (2974607)2974607..2975335-729WP_004178298.1response regulator transcription factor-
M4269_RS14400 (2975608)2975608..2977755+2148WP_012737173.1formate dehydrogenase H subunit alpha, selenocysteine-containing-
M4269_RS14405 (2977985)2977985..2978671+687WP_004151733.1tetratricopeptide repeat protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T244991 WP_004178299.1 NZ_CP097232:c2973757-2972840 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT244991 WP_004177809.1 NZ_CP097232:c2974521-2973763 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA6TH05

References