Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 2972840..2974521 | Replicon | chromosome |
Accession | NZ_CP097232 | ||
Organism | Klebsiella pneumoniae strain 4 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | - |
Locus tag | M4269_RS14385 | Protein ID | WP_004178299.1 |
Coordinates | 2972840..2973757 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A6TH05 |
Locus tag | M4269_RS14390 | Protein ID | WP_004177809.1 |
Coordinates | 2973763..2974521 (-) | Length | 253 a.a. |
Genomic Context
Location: 2968146..2969666 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
Type: Others
Protein ID: WP_002885173.1
Location: 2969663..2970661 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Type: Others
Protein ID: WP_002885172.1
Location: 2970692..2971633 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Type: Others
Protein ID: WP_002885156.1
Location: 2971708..2972715 (1008 bp)
Type: Others
Protein ID: WP_004178300.1
Type: Others
Protein ID: WP_004178300.1
Location: 2975608..2977755 (2148 bp)
Type: Others
Protein ID: WP_012737173.1
Type: Others
Protein ID: WP_012737173.1
Location: 2977985..2978671 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Type: Others
Protein ID: WP_004151733.1
Location: 2972840..2973757 (918 bp)
Type: Toxin
Protein ID: WP_004178299.1
Type: Toxin
Protein ID: WP_004178299.1
Location: 2973763..2974521 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 2974607..2975335 (729 bp)
Type: Others
Protein ID: WP_004178298.1
Type: Others
Protein ID: WP_004178298.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M4269_RS14365 (2968146) | 2968146..2969666 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
M4269_RS14370 (2969663) | 2969663..2970661 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
M4269_RS14375 (2970692) | 2970692..2971633 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
M4269_RS14380 (2971708) | 2971708..2972715 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
M4269_RS14385 (2972840) | 2972840..2973757 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
M4269_RS14390 (2973763) | 2973763..2974521 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
M4269_RS14395 (2974607) | 2974607..2975335 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
M4269_RS14400 (2975608) | 2975608..2977755 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
M4269_RS14405 (2977985) | 2977985..2978671 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T244991 WP_004178299.1 NZ_CP097232:c2973757-2972840 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT244991 WP_004177809.1 NZ_CP097232:c2974521-2973763 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A6TH05 |