Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2817145..2817661 Replicon chromosome
Accession NZ_CP097232
Organism Klebsiella pneumoniae strain 4

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4269_RS13590 Protein ID WP_004178374.1
Coordinates 2817145..2817429 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4269_RS13595 Protein ID WP_002886901.1
Coordinates 2817419..2817661 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4269_RS13565 (2812629) 2812629..2812892 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M4269_RS13570 (2813022) 2813022..2813195 + 174 WP_032408826.1 hypothetical protein -
M4269_RS13575 (2813198) 2813198..2813941 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4269_RS13580 (2814298) 2814298..2816436 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4269_RS13585 (2816677) 2816677..2817141 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4269_RS13590 (2817145) 2817145..2817429 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4269_RS13595 (2817419) 2817419..2817661 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4269_RS13600 (2817739) 2817739..2819649 - 1911 WP_004178373.1 PRD domain-containing protein -
M4269_RS13605 (2819672) 2819672..2820826 - 1155 WP_004178372.1 lactonase family protein -
M4269_RS13610 (2820893) 2820893..2821633 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T244990 WP_004178374.1 NZ_CP097232:c2817429-2817145 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244990 WP_002886901.1 NZ_CP097232:c2817661-2817419 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References