Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 502064..503652 Replicon chromosome
Accession NZ_CP097232
Organism Klebsiella pneumoniae strain 4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M4269_RS02520 Protein ID WP_004179815.1
Coordinates 502330..503652 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M4269_RS02515 Protein ID WP_004176198.1
Coordinates 502064..502330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4269_RS02490 (497214) 497214..498137 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
M4269_RS02495 (498118) 498118..499272 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M4269_RS02500 (499618) 499618..500997 + 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M4269_RS02505 (500975) 500975..501475 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M4269_RS02510 (501472) 501472..501798 + 327 WP_002904788.1 hydroxyisourate hydrolase -
M4269_RS02515 (502064) 502064..502330 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M4269_RS02520 (502330) 502330..503652 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M4269_RS02525 (503669) 503669..504961 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M4269_RS02530 (505103) 505103..506107 - 1005 WP_004179822.1 fimbrial protein -
M4269_RS02535 (506095) 506095..508596 - 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T244982 WP_004179815.1 NZ_CP097232:502330-503652 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT244982 WP_004176198.1 NZ_CP097232:502064-502330 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References