244979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 137687..138209 Replicon plasmid p390.4
Accession NZ_CP097229
Organism Klebsiella pneumoniae strain 5

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag M4270_RS26495 Protein ID WP_038991638.1
Coordinates 137925..138209 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag M4270_RS26490 Protein ID WP_004181777.1
Coordinates 137687..137935 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4270_RS26470 (M4270_26465) 132896..133717 - 822 WP_004181772.1 hypothetical protein -
M4270_RS26475 (M4270_26470) 133779..134132 - 354 WP_004181774.1 hypothetical protein -
M4270_RS26480 (M4270_26475) 134277..135263 - 987 WP_040120328.1 hypothetical protein -
M4270_RS26485 (M4270_26480) 135597..137396 - 1800 WP_043907032.1 ATP-dependent helicase -
M4270_RS26490 (M4270_26485) 137687..137935 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M4270_RS26495 (M4270_26490) 137925..138209 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4270_RS26500 (M4270_26495) 138226..138327 - 102 Protein_146 IS200/IS605 family transposase -
M4270_RS26505 (M4270_26500) 138363..139589 + 1227 WP_040120327.1 RNA-guided endonuclease TnpB family protein -
M4270_RS26510 (M4270_26505) 139861..140085 - 225 Protein_148 transposase -
M4270_RS26515 (M4270_26510) 140164..140592 - 429 WP_077256229.1 IS200/IS605 family transposase -
M4270_RS26520 (M4270_26515) 140628..141815 + 1188 WP_043907031.1 RNA-guided endonuclease TnpB family protein -
M4270_RS26525 (M4270_26520) 141860..142231 - 372 WP_044816264.1 hypothetical protein -
M4270_RS26530 (M4270_26525) 142228..142572 - 345 WP_014386518.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / qnrB1 htpB 1..390420 390420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T244979 WP_038991638.1 NZ_CP097229:137925-138209 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT244979 WP_004181777.1 NZ_CP097229:137687-137935 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References