244977

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4405537..4406194 Replicon chromosome
Accession NZ_CP097228
Organism Klebsiella pneumoniae strain 5

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M4270_RS21265 Protein ID WP_004181233.1
Coordinates 4405784..4406194 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M4270_RS21260 Protein ID WP_002916312.1
Coordinates 4405537..4405803 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4270_RS21235 (4400693) 4400693..4402126 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
M4270_RS21240 (4402245) 4402245..4402973 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M4270_RS21245 (4403023) 4403023..4403334 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M4270_RS21250 (4403498) 4403498..4404157 + 660 WP_002916317.1 hemolysin III family protein -
M4270_RS21255 (4404308) 4404308..4405291 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M4270_RS21260 (4405537) 4405537..4405803 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M4270_RS21265 (4405784) 4405784..4406194 + 411 WP_004181233.1 protein YgfX Toxin
M4270_RS21270 (4406201) 4406201..4406722 - 522 WP_004144730.1 flavodoxin FldB -
M4270_RS21275 (4406823) 4406823..4407719 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M4270_RS21280 (4407742) 4407742..4408455 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4270_RS21285 (4408461) 4408461..4410194 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T244977 WP_004181233.1 NZ_CP097228:4405784-4406194 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244977 WP_002916312.1 NZ_CP097228:4405537-4405803 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References