Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3499372..3499997 Replicon chromosome
Accession NZ_CP097228
Organism Klebsiella pneumoniae strain 5

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M4270_RS16835 Protein ID WP_002882817.1
Coordinates 3499372..3499755 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M4270_RS16840 Protein ID WP_004150355.1
Coordinates 3499755..3499997 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4270_RS16820 (3496738) 3496738..3497640 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M4270_RS16825 (3497637) 3497637..3498272 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M4270_RS16830 (3498269) 3498269..3499198 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M4270_RS16835 (3499372) 3499372..3499755 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M4270_RS16840 (3499755) 3499755..3499997 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M4270_RS16845 (3500202) 3500202..3501119 + 918 WP_004181612.1 alpha/beta hydrolase -
M4270_RS16850 (3501133) 3501133..3502074 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M4270_RS16855 (3502119) 3502119..3502556 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M4270_RS16860 (3502553) 3502553..3503413 - 861 WP_004146232.1 virulence factor BrkB family protein -
M4270_RS16865 (3503407) 3503407..3504006 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T244975 WP_002882817.1 NZ_CP097228:c3499755-3499372 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT244975 WP_004150355.1 NZ_CP097228:c3499997-3499755 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References