Detailed information of TA system TA244974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3186613..3188294
• Replicon: chromosome
• Accession: NZ_CP097228
• Organism: Klebsiella pneumoniae strain 5

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M4270_RS15400
• Protein ID: WP_004178299.1
• Coordinates: 3186613..3187530 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M4270_RS15405
• Protein ID: WP_004177809.1
• Coordinates: 3187536..3188294 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M4270_RS15380 (3181919)	3181919..3183439	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M4270_RS15385 (3183436)	3183436..3184434	+	999	WP_002885172.1	ribose ABC transporter permease	-
M4270_RS15390 (3184465)	3184465..3185406	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M4270_RS15395 (3185481)	3185481..3186488	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M4270_RS15400 (3186613)	3186613..3187530	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M4270_RS15405 (3187536)	3187536..3188294	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M4270_RS15410 (3188380)	3188380..3189108	-	729	WP_004178298.1	response regulator transcription factor	-
M4270_RS15415 (3189381)	3189381..3191528	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M4270_RS15420 (3191758)	3191758..3192444	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T244974 WP_004178299.1 NZ_CP097228:c3187530-3186613 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT244974 WP_004177809.1 NZ_CP097228:c3188294-3187536 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05