244973

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3030918..3031434 Replicon chromosome
Accession NZ_CP097228
Organism Klebsiella pneumoniae strain 5

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4270_RS14605 Protein ID WP_004178374.1
Coordinates 3030918..3031202 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4270_RS14610 Protein ID WP_002886901.1
Coordinates 3031192..3031434 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4270_RS14580 (3026402) 3026402..3026665 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M4270_RS14585 (3026795) 3026795..3026968 + 174 WP_032408826.1 hypothetical protein -
M4270_RS14590 (3026971) 3026971..3027714 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4270_RS14595 (3028071) 3028071..3030209 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4270_RS14600 (3030450) 3030450..3030914 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4270_RS14605 (3030918) 3030918..3031202 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4270_RS14610 (3031192) 3031192..3031434 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4270_RS14615 (3031512) 3031512..3033422 - 1911 WP_004178373.1 PRD domain-containing protein -
M4270_RS14620 (3033445) 3033445..3034599 - 1155 WP_004178372.1 lactonase family protein -
M4270_RS14625 (3034666) 3034666..3035406 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T244973 WP_004178374.1 NZ_CP097228:c3031202-3030918 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244973 WP_002886901.1 NZ_CP097228:c3031434-3031192 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References