Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 573537..574157 Replicon chromosome
Accession NC_013716
Organism Citrobacter rodentium ICC168

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ROD_RS02595 Protein ID WP_002892050.1
Coordinates 573537..573755 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2TLT7
Locus tag ROD_RS02600 Protein ID WP_012904868.1
Coordinates 573783..574157 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ROD_RS02565 569061..569630 + 570 WP_012904863.1 YbaY family lipoprotein -
ROD_RS02570 569662..569973 - 312 WP_012904864.1 MGMT family protein -
ROD_RS02575 570326..571876 - 1551 WP_012904865.1 EAL domain-containing protein -
ROD_RS02580 572044..572184 + 141 WP_024132524.1 type B 50S ribosomal protein L36 -
ROD_RS02585 572225..572695 - 471 WP_012904866.1 YlaC family protein -
ROD_RS02590 572796..573359 - 564 WP_012904867.1 maltose O-acetyltransferase -
ROD_RS02595 573537..573755 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ROD_RS02600 573783..574157 - 375 WP_012904868.1 Hha toxicity modulator TomB Antitoxin
ROD_RS02605 574651..577800 - 3150 WP_012904869.1 multidrug efflux RND transporter permease subunit -
ROD_RS02610 577823..579016 - 1194 WP_012904870.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T24497 WP_002892050.1 NC_013716:c573755-573537 [Citrobacter rodentium ICC168]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T24497 NC_013716:c573755-573537 [Citrobacter rodentium ICC168]
ATGTCCGATAAACCATTAACTAAAACTGATTACTTGATGCGTTTACGACGCTGCCAGACAATTGATACACTTGAGCGTGT
GATTGAAAAAAATAAATATGAATTATCTGACAACGAACTGGCCGTATTTTACTCAGCGGCGGATCACCGTCTTGCAGAAT
TAACCATGAATAAACTGTACGACAAAATTCCCACTTCCGTGTGGAAGTTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14496.27 Da        Isoelectric Point: 4.8990

>AT24497 WP_012904868.1 NC_013716:c574157-573783 [Citrobacter rodentium ICC168]
MDEYSPKRHDIAQLKFLCETLYHDSLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQLDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVTATRANPVSLSC

Download         Length: 375 bp

>AT24497 NC_013716:c574157-573783 [Citrobacter rodentium ICC168]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAATTTCTTTGTGAAACGCTTTATCATGACAGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCAATCAACCTTCAACTCAACGAACTGATAGAGC
ATATTGCCACATTCGCACTTAATTATAAGATTAAGTACAATGAGGACAATAAGCTGATTGAGCAGCTCGATGAATATCTG
GACGACACATTTATGTTGTTCAGCAGTTACGGCATTAATACGCAGGATCTGCAAAAATGGCGGAAATCGGGAAACCGCTT
GTTTCGCTGCTTTGTGACTGCCACTAGGGCGAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB D2TLT7

References