Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 92630..93381 Replicon plasmid p235.4
Accession NZ_CP097224
Organism Klebsiella pneumoniae strain 11

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag M4271_RS26305 Protein ID WP_014386536.1
Coordinates 92899..93381 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M4271_RS26300 Protein ID WP_004902250.1
Coordinates 92630..92908 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4271_RS26265 (M4271_26265) 88273..88698 - 426 WP_000522996.1 organomercurial transporter MerC -
M4271_RS26270 (M4271_26270) 88726..89001 - 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
M4271_RS26275 (M4271_26275) 89017..89382 - 366 WP_004200999.1 mercuric ion transporter MerT -
M4271_RS26280 (M4271_26280) 89454..89909 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
M4271_RS26285 (M4271_26285) 90562..91020 + 459 WP_014386535.1 hypothetical protein -
M4271_RS26290 (M4271_26290) 91850..92191 + 342 WP_004902257.1 hypothetical protein -
M4271_RS26295 (M4271_26295) 92299..92511 + 213 WP_004902255.1 hypothetical protein -
M4271_RS26300 (M4271_26300) 92630..92908 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M4271_RS26305 (M4271_26305) 92899..93381 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
M4271_RS26310 (M4271_26310) 94416..94955 + 540 WP_004902239.1 hypothetical protein -
M4271_RS26315 (M4271_26315) 95060..95452 + 393 WP_032442757.1 hypothetical protein -
M4271_RS26320 (M4271_26320) 95553..96308 + 756 WP_004902235.1 DUF2971 domain-containing protein -
M4271_RS26325 (M4271_26325) 96335..96982 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / aph(6)-Id / aph(3'')-Ib / sul2 / aph(3')-VI / blaNDM-1 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..235390 235390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T244961 WP_014386536.1 NZ_CP097224:92899-93381 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT244961 WP_004902250.1 NZ_CP097224:92630-92908 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References