Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3505108..3505733 Replicon chromosome
Accession NZ_CP097223
Organism Klebsiella pneumoniae strain 11

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M4271_RS16860 Protein ID WP_002882817.1
Coordinates 3505108..3505491 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M4271_RS16865 Protein ID WP_004150355.1
Coordinates 3505491..3505733 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4271_RS16845 (3502474) 3502474..3503376 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M4271_RS16850 (3503373) 3503373..3504008 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M4271_RS16855 (3504005) 3504005..3504934 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M4271_RS16860 (3505108) 3505108..3505491 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M4271_RS16865 (3505491) 3505491..3505733 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M4271_RS16870 (3505938) 3505938..3506855 + 918 WP_004181612.1 alpha/beta hydrolase -
M4271_RS16875 (3506869) 3506869..3507810 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M4271_RS16880 (3507855) 3507855..3508292 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M4271_RS16885 (3508289) 3508289..3509149 - 861 WP_004146232.1 virulence factor BrkB family protein -
M4271_RS16890 (3509143) 3509143..3509742 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T244958 WP_002882817.1 NZ_CP097223:c3505491-3505108 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT244958 WP_004150355.1 NZ_CP097223:c3505733-3505491 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References