Detailed information of TA system TA244957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3192349..3194030
• Replicon: chromosome
• Accession: NZ_CP097223
• Organism: Klebsiella pneumoniae strain 11

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M4271_RS15425
• Protein ID: WP_004178299.1
• Coordinates: 3192349..3193266 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M4271_RS15430
• Protein ID: WP_004177809.1
• Coordinates: 3193272..3194030 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M4271_RS15405 (3187655)	3187655..3189175	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M4271_RS15410 (3189172)	3189172..3190170	+	999	WP_002885172.1	ribose ABC transporter permease	-
M4271_RS15415 (3190201)	3190201..3191142	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M4271_RS15420 (3191217)	3191217..3192224	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M4271_RS15425 (3192349)	3192349..3193266	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M4271_RS15430 (3193272)	3193272..3194030	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M4271_RS15435 (3194116)	3194116..3194844	-	729	WP_004178298.1	response regulator transcription factor	-
M4271_RS15440 (3195117)	3195117..3197264	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M4271_RS15445 (3197494)	3197494..3198180	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T244957 WP_004178299.1 NZ_CP097223:c3193266-3192349 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT244957 WP_004177809.1 NZ_CP097223:c3194030-3193272 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05