Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3036654..3037170 Replicon chromosome
Accession NZ_CP097223
Organism Klebsiella pneumoniae strain 11

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4271_RS14630 Protein ID WP_004178374.1
Coordinates 3036654..3036938 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4271_RS14635 Protein ID WP_002886901.1
Coordinates 3036928..3037170 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4271_RS14605 (3032138) 3032138..3032446 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
M4271_RS14610 (3032531) 3032531..3032704 + 174 WP_032408826.1 hypothetical protein -
M4271_RS14615 (3032707) 3032707..3033450 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4271_RS14620 (3033807) 3033807..3035945 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4271_RS14625 (3036186) 3036186..3036650 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4271_RS14630 (3036654) 3036654..3036938 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4271_RS14635 (3036928) 3036928..3037170 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4271_RS14640 (3037248) 3037248..3039158 - 1911 WP_004178373.1 PRD domain-containing protein -
M4271_RS14645 (3039181) 3039181..3040335 - 1155 WP_004178372.1 lactonase family protein -
M4271_RS14650 (3040402) 3040402..3041142 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T244956 WP_004178374.1 NZ_CP097223:c3036938-3036654 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244956 WP_002886901.1 NZ_CP097223:c3037170-3036928 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References