Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 722347..723935 Replicon chromosome
Accession NZ_CP097223
Organism Klebsiella pneumoniae strain 11

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M4271_RS03570 Protein ID WP_004179815.1
Coordinates 722613..723935 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M4271_RS03565 Protein ID WP_004176198.1
Coordinates 722347..722613 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4271_RS03540 (717497) 717497..718420 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
M4271_RS03545 (718401) 718401..719555 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M4271_RS03550 (719901) 719901..721280 + 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M4271_RS03555 (721258) 721258..721758 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M4271_RS03560 (721755) 721755..722081 + 327 WP_002904788.1 hydroxyisourate hydrolase -
M4271_RS03565 (722347) 722347..722613 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M4271_RS03570 (722613) 722613..723935 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M4271_RS03575 (723952) 723952..725244 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M4271_RS03580 (725386) 725386..726390 - 1005 WP_004179822.1 fimbrial protein -
M4271_RS03585 (726378) 726378..728879 - 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T244948 WP_004179815.1 NZ_CP097223:722613-723935 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT244948 WP_004176198.1 NZ_CP097223:722347-722613 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References