Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4905025..4905541 Replicon chromosome
Accession NZ_CP097220
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4272_RS23800 Protein ID WP_004178374.1
Coordinates 4905257..4905541 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4272_RS23795 Protein ID WP_002886901.1
Coordinates 4905025..4905267 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4272_RS23780 (4901053) 4901053..4901793 + 741 WP_002886899.1 KDGP aldolase family protein -
M4272_RS23785 (4901860) 4901860..4903014 + 1155 WP_004178372.1 lactonase family protein -
M4272_RS23790 (4903037) 4903037..4904947 + 1911 WP_004178373.1 PRD domain-containing protein -
M4272_RS23795 (4905025) 4905025..4905267 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4272_RS23800 (4905257) 4905257..4905541 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4272_RS23805 (4905545) 4905545..4906009 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4272_RS23810 (4906250) 4906250..4908388 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4272_RS23815 (4908745) 4908745..4909488 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4272_RS23820 (4909491) 4909491..4909664 - 174 WP_032408826.1 hypothetical protein -
M4272_RS23825 (4909794) 4909794..4910057 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T244943 WP_004178374.1 NZ_CP097220:4905257-4905541 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244943 WP_002886901.1 NZ_CP097220:4905025-4905267 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References