Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4436612..4437237 Replicon chromosome
Accession NZ_CP097220
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M4272_RS21575 Protein ID WP_002882817.1
Coordinates 4436854..4437237 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M4272_RS21570 Protein ID WP_004150355.1
Coordinates 4436612..4436854 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4272_RS21545 (4432603) 4432603..4433202 + 600 WP_004151865.1 glucose-1-phosphatase -
M4272_RS21550 (4433196) 4433196..4434056 + 861 WP_004146232.1 virulence factor BrkB family protein -
M4272_RS21555 (4434053) 4434053..4434490 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M4272_RS21560 (4434535) 4434535..4435476 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M4272_RS21565 (4435490) 4435490..4436407 - 918 WP_004181612.1 alpha/beta hydrolase -
M4272_RS21570 (4436612) 4436612..4436854 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M4272_RS21575 (4436854) 4436854..4437237 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M4272_RS21580 (4437411) 4437411..4438340 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M4272_RS21585 (4438337) 4438337..4438972 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M4272_RS21590 (4438969) 4438969..4439871 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T244941 WP_002882817.1 NZ_CP097220:4436854-4437237 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT244941 WP_004150355.1 NZ_CP097220:4436612-4436854 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References