Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3530416..3531073 Replicon chromosome
Accession NZ_CP097220
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M4272_RS17150 Protein ID WP_004181233.1
Coordinates 3530416..3530826 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M4272_RS17155 Protein ID WP_002916312.1
Coordinates 3530807..3531073 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4272_RS17130 (3526416) 3526416..3528149 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
M4272_RS17135 (3528155) 3528155..3528868 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4272_RS17140 (3528891) 3528891..3529787 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M4272_RS17145 (3529888) 3529888..3530409 + 522 WP_004144730.1 flavodoxin FldB -
M4272_RS17150 (3530416) 3530416..3530826 - 411 WP_004181233.1 protein YgfX Toxin
M4272_RS17155 (3530807) 3530807..3531073 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M4272_RS17160 (3531319) 3531319..3532302 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M4272_RS17165 (3532453) 3532453..3533112 - 660 WP_002916317.1 hemolysin III family protein -
M4272_RS17170 (3533276) 3533276..3533587 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M4272_RS17175 (3533637) 3533637..3534365 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M4272_RS17180 (3534484) 3534484..3535917 + 1434 WP_004181234.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T244939 WP_004181233.1 NZ_CP097220:c3530826-3530416 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244939 WP_002916312.1 NZ_CP097220:c3531073-3530807 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References