Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1873235..1874823 Replicon chromosome
Accession NZ_CP097220
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M4272_RS09090 Protein ID WP_004179815.1
Coordinates 1873235..1874557 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M4272_RS09095 Protein ID WP_004176198.1
Coordinates 1874557..1874823 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4272_RS09075 (1868291) 1868291..1870792 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
M4272_RS09080 (1870780) 1870780..1871784 + 1005 WP_004179822.1 fimbrial protein -
M4272_RS09085 (1871926) 1871926..1873218 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M4272_RS09090 (1873235) 1873235..1874557 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M4272_RS09095 (1874557) 1874557..1874823 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M4272_RS09100 (1875089) 1875089..1875415 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M4272_RS09105 (1875412) 1875412..1875912 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M4272_RS09110 (1875890) 1875890..1877269 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M4272_RS09115 (1877615) 1877615..1878769 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M4272_RS09120 (1878750) 1878750..1879673 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T244938 WP_004179815.1 NZ_CP097220:c1874557-1873235 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT244938 WP_004176198.1 NZ_CP097220:c1874823-1874557 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References