Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 103722..104365 Replicon plasmid unnamed1
Accession NZ_CP097214
Organism Escherichia coli strain BE311

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag M3O69_RS23970 Protein ID WP_001044768.1
Coordinates 103949..104365 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag M3O69_RS23965 Protein ID WP_001261287.1
Coordinates 103722..103952 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3O69_RS23960 (100297) 100297..103416 - 3120 WP_000467135.1 hypothetical protein -
M3O69_RS23965 (103722) 103722..103952 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M3O69_RS23970 (103949) 103949..104365 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
M3O69_RS23975 (104527) 104527..106665 - 2139 WP_000350635.1 AAA family ATPase -
M3O69_RS23980 (107019) 107019..107276 + 258 WP_000371887.1 hypothetical protein -
M3O69_RS23985 (107276) 107276..107866 + 591 WP_000194548.1 hypothetical protein -
M3O69_RS23990 (107884) 107884..108231 - 348 WP_000142443.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - paa 1..113297 113297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T244930 WP_001044768.1 NZ_CP097214:103949-104365 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT244930 WP_001261287.1 NZ_CP097214:103722-103952 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References