244929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 75418..76043 Replicon plasmid unnamed1
Accession NZ_CP097214
Organism Escherichia coli strain BE311

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3O69_RS23840 Protein ID WP_000911314.1
Coordinates 75418..75816 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag M3O69_RS23845 Protein ID WP_000450532.1
Coordinates 75816..76043 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3O69_RS23825 (71749) 71749..72258 + 510 WP_000628103.1 conjugal transfer entry exclusion protein TraS -
M3O69_RS23830 (72272) 72272..73003 + 732 WP_000850426.1 conjugal transfer complement resistance protein TraT -
M3O69_RS23835 (73256) 73256..75409 + 2154 WP_001375140.1 type IV conjugative transfer system coupling protein TraD -
M3O69_RS23840 (75418) 75418..75816 - 399 WP_000911314.1 type II toxin-antitoxin system VapC family toxin Toxin
M3O69_RS23845 (75816) 75816..76043 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - paa 1..113297 113297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14814.12 Da        Isoelectric Point: 7.8604

>T244929 WP_000911314.1 NZ_CP097214:c75816-75418 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT244929 WP_000450532.1 NZ_CP097214:c76043-75816 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References