Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/ElaA-DUF1778
Location 27788..28591 Replicon plasmid unnamed1
Accession NZ_CP097214
Organism Escherichia coli strain BE311

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag M3O69_RS23530 Protein ID WP_000348879.1
Coordinates 28061..28591 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag M3O69_RS23525 Protein ID WP_000114669.1
Coordinates 27788..28057 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3O69_RS23500 (24207) 24207..24893 + 687 WP_001031857.1 fimbrial chaperone -
M3O69_RS23505 (24893) 24893..25894 + 1002 WP_000792596.1 protein FanF -
M3O69_RS23510 (25894) 25894..26418 + 525 WP_000737845.1 spore coat protein U domain-containing protein -
M3O69_RS23515 (26411) 26411..26938 + 528 WP_000592915.1 hypothetical protein -
M3O69_RS23520 (27099) 27099..27595 + 497 Protein_32 tyrosine-type recombinase/integrase -
M3O69_RS23525 (27788) 27788..28057 + 270 WP_000114669.1 DUF1778 domain-containing protein Antitoxin
M3O69_RS23530 (28061) 28061..28591 + 531 WP_000348879.1 GNAT family N-acetyltransferase Toxin
M3O69_RS23535 (29103) 29103..29321 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
M3O69_RS23540 (29323) 29323..29628 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
M3O69_RS23545 (29629) 29629..30435 + 807 WP_000016982.1 site-specific integrase -
M3O69_RS23550 (31157) 31157..31483 + 327 Protein_38 RepB family plasmid replication initiator protein -
M3O69_RS23560 (32808) 32808..33248 + 441 Protein_40 RepB family plasmid replication initiator protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - paa 1..113297 113297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-156)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 20402.29 Da        Isoelectric Point: 6.6389

>T244924 WP_000348879.1 NZ_CP097214:28061-28591 [Escherichia coli]
MDGLRIEIFSEEVEYELSNFDCGEEYLNTFLTDHLKRQHNSKILRGYLLVTREDKPRVMGYYTLSGSCFEKTLLPSKTQQ
KRVPYKNVPSVTLGRLAIDKNLHRQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKKFYLRMGFIQLKEENCNSL
FYPTKSIEELFEVNDE

Download         Length: 531 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10341.85 Da        Isoelectric Point: 6.4742

>AT244924 WP_000114669.1 NZ_CP097214:27788-28057 [Escherichia coli]
MSVLKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLLLNEESWNLVMDAITNPPVPNERLKR
AAKRLRELE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References