244901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1292755..1293672 Replicon chromosome
Accession NZ_CP097208
Organism Bacillus velezensis strain N3

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag M2893_RS06735 Protein ID WP_003154806.1
Coordinates 1292926..1293672 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M2893_RS06730 Protein ID WP_003154807.1
Coordinates 1292755..1292925 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2893_RS06690 (1287987) 1287987..1289609 + 1623 WP_063174222.1 pyocin knob domain-containing protein -
M2893_RS06695 (1289622) 1289622..1289993 + 372 WP_014304856.1 XkdW family protein -
M2893_RS06700 (1289999) 1289999..1290196 + 198 WP_003154819.1 XkdX family protein -
M2893_RS06705 (1290253) 1290253..1291014 + 762 WP_063174221.1 hypothetical protein -
M2893_RS06710 (1291066) 1291066..1291329 + 264 WP_032866112.1 hemolysin XhlA family protein -
M2893_RS06715 (1291343) 1291343..1291606 + 264 WP_003154813.1 phage holin -
M2893_RS06720 (1291620) 1291620..1292498 + 879 WP_024085195.1 N-acetylmuramoyl-L-alanine amidase -
M2893_RS06725 (1292533) 1292533..1292658 - 126 WP_003154809.1 hypothetical protein -
M2893_RS06730 (1292755) 1292755..1292925 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M2893_RS06735 (1292926) 1292926..1293672 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M2893_RS06740 (1293777) 1293777..1294775 - 999 WP_003154805.1 inorganic phosphate transporter -
M2893_RS06745 (1294788) 1294788..1295405 - 618 WP_003154804.1 DUF47 domain-containing protein -
M2893_RS06750 (1295691) 1295691..1297007 - 1317 WP_003154801.1 amino acid permease -
M2893_RS06755 (1297330) 1297330..1298280 + 951 WP_015388352.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T244901 WP_003154806.1 NZ_CP097208:c1293672-1292926 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT244901 WP_003154807.1 NZ_CP097208:c1292925-1292755 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References